Testosterone Replacement Therapy Explained

A physician goes over printed blood test results with a man in his fifties during a consultation

Testosterone replacement therapy, or TRT, is doctor-prescribed treatment for men whose testosterone stays low. Most readers arrive after noticing a change and wondering whether it deserves a blood test.

What the Endocrine Society says about treatment

The Endocrine Society says doctor-prescribed testosterone replacement therapy can treat hypogonadism, and that it is safe and can be effective for men diagnosed with consistently abnormal low testosterone production and symptoms of hormone deficiency.

A separate Endocrine Society statement says TRT at a dosage similar to what a man would typically make has clear benefits for men with appropriately diagnosed hypogonadism caused by a disease of the testes, pituitary or hypothalamus. The same statement says weight loss is typically the first-line therapy when hypogonadism is diagnosed in an overweight or obese man, with a BMI above 27 and no other identified cause.

The Endocrine Society's full statement on testosterone replacement therapy sets out its position in detail. A narrative review of testosterone therapy in men aged 50 and above, indexed in PMC, covers benefits, safety considerations and clinical recommendations.

Pages sorted by how soon the question needs an answer

Start with the question you are asking today.

Symptoms of Low Testosterone in Men helps when you have noticed a change and want to know whether it fits. How Doctors Diagnose Low Testosterone comes next, when you are deciding whether to book a visit and ask for blood tests.

Common Causes of Low T is the background read and suits a calmer moment. Testosterone Pellet Warnings and Side Effects is for readers who already have pellets or are weighing them.

Choosing your page

Not sure where to begin? Open the symptoms page first. If you already have a result in hand, go to the diagnosis page.

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